Wattle Pharmacy Prep

Pharmaceutical calculations
Practice questions with explanations

Pharmaceutical calculations belongs to Therapeutics and patient care, which makes up about 45% of the Overseas Pharmacist Readiness Assessment (OPRA®). Answer each question yourself before opening the explanation.

1. A child weighing 25 kg is prescribed a drug at 20 mg/kg/day in two divided doses. What is each dose?

  1. 1000 mg
  2. 250 mg
  3. 500 mg
  4. 125 mg
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B. 250 mg

The daily dose is 25 x 20 = 500 mg, divided into two gives 250 mg per dose. Reading whether a reference expresses the dose per day or per dose is the decisive step, since treating 20 mg/kg as the individual dose would double the intended daily amount.

2. A child weighing 8 kg needs a drug at 30 mg/kg/day in three divided doses. The suspension contains 125 mg in 5 mL. What volume per dose?

  1. 6.4 mL
  2. 9.6 mL
  3. 3.2 mL
  4. 1.6 mL
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C. 3.2 mL

The daily dose is 8 x 30 = 240 mg, divided into three gives 80 mg per dose. The suspension provides 25 mg/mL, so 80 divided by 25 gives 3.2 mL. Working stepwise from daily dose to individual dose to volume keeps each conversion visible and checkable.

3. How many grams of active ingredient are in 500 mL of a 5% w/v solution?

  1. 5 g
  2. 50 g
  3. 25 g
  4. 2.5 g
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C. 25 g

Per cent w/v means grams of solute in 100 mL of solution, so 5% w/v is 5 g per 100 mL. In 500 mL there are five such portions: 5 x 5 = 25 g. Keeping the definition in mind avoids the common slip of treating w/v as grams per litre.

These are 3 of the 80 questions on pharmaceutical calculations in the app.

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